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Without IGFBP binding, IGF-1 LR3 remains in free, receptor-accessible form for 56–72 hours — substantially longer than native IGF-1's 10–20-minute half-life when not IGFBP-bound

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It was interesting to note that, at the higher concentrations of 0.5ug/ml and 1 μg/ml, we observed lower rate of telomere extension for BT474 when compared to the maximum length obtained at 0.2ug/ml